Video: Laura Gonzalez speaks at ASU – Seminar

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Speaker: Laura Gonzalez, Ph.D., Postdoctoral Research Associate, Center for Personalized Diagnostics, The Biodesign Institute

Date & Time: May 20th, 2010 12:00 p.m.

Title: Functional Genomics and Proteomics to understand tamoxifen resistance


Functional Genomics and Proteomics to understand tamoxifen resistance

We are pursuing studies to identify and characterize genes that regulate critical events involved in the development of resistance to hormonal therapies in breast cancer. Approximately two-thirds of breast cancers require estrogen to grow. Estrogen receptor (ER) – the protein activated by estrogen, and the proteins that it activates – are excellent targets for hormonal therapy in these patients. Tamoxifen is an anti-estrogen drug that has been the gold standard for hormonal therapy at all stages of breast cancer, and has improved patient survival. However, the success of tamoxifen therapy is limited by natural and/or acquired tumor resistance. Approximately 40{236bd5e292587b885399ce1fe93b84c86ca4f34851d3c4bf06f3f0da35a3ccbb} of ER patients will not respond to tamoxifen therapy, and major efforts are underway to understand the reasons.

In our lab, we produced a series of breast cancer cell lines that were either highly sensitive or naturally resistant to tamoxifen. We are using these cells to study the factors that lead to drug resistance, through the use of gene expression profiles and high throughput approaches.

One Response to “Video: Laura Gonzalez speaks at ASU – Seminar”

  1. Hewlett says:

    More and more researches have been formulated to better understand and treat cancer. I’ve heard that cancer has no cure and I am glad to know that people are trying their best to grasp it better to be able to treat it. My father died of cancer and would like to also take part in fighting against it.

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