Thai Tran – Discovery of Prolactin Signaling Pathway in Breast Cancer

Speaker: Thai Tran, PhD. received his Ph.D. in molecular biology from Purdue University and was trained a as a postdoctoral fellow with Dr. Hallgeir Rui at the Kimmel Cancer Center, Thomas Jefferson University. Dr. Tran has background in molecular and cellular biology of cancer. His research focus is to investigate the molecular functions that govern cancer cell development and progression. Specifically, his research has centered on identifying molecular biomarkers in breast, pancreatic and esophagus cancers using the combined approaches of high throughput immunohistochemistry, molecular and cellular technologies. More recently, he has focused more on dissecting intratumoral heterogeneity at the single-cell level by analyzing gene expression profiles of individual cells freshly isolated from true human clinical samples. The primary goal of this study is to identify minute populations of cells that potentially play major roles in cancer progression and metastasis.

Location: Biodesign Auditorium

Web Cast: View Web Cast Video

Date & Time: October 20th, 2011 12:00 p.m.

Title: Discovery of Prolactin Signaling Pathway in Breast Cancer

Abstract: Breast cancer is the second leading cause of deaths among women. In the United States, an estimated 230,480 are diagnosed with breast cancer each year and, of these, 39,520 are expected to die from the disease. This devastating consequence is partly due our inability to detect and provide treatments while the tumor is localized to the breast. As a result, numerous efforts have been made to identify early breast cancer biomarkers. In my talk I will discuss the implications of a number of potential breast cancer biomarkers specifically focusing on the functions of prolactin and its downstream target, Stat5. Unraveling the details of this new mechanism illustrates the complexity of signaling pathways and the formidable challenge of designing chemical intervention.

Thank you and if you have questions please contact Amanda Wilber! And don’t forget, coffee will be served!

Amanda Wilber, Center for the Convergence of Physical Science and Cancer Biology

Arizona State University | P.O. Box 871504 | Tempe, AZ 85287

480.965.3860 | Fax: 480.965.6362
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